General Information

  • ID:  hor001392
  • Uniprot ID:  A0A0L0BTP1
  • Protein name:  FMRFamide-18
  • Gene name:  NA
  • Organism:  Lucilia cuprina (Green bottle fly) (Australian sheep blowfly)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Lucilia (genus), Luciliinae (subfamily), Calliphoridae (family), Oestroidea (superfamily), Calyptratae, Schizophora, Cyclorrhapha, Eremoneura, Muscomorpha (infraorder), Brachycera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  TPPQPSDNFIRF
  • Length:  12
  • Propeptide:  FSFNKVLFLALQLCYTQTLSKVVNDPQYGINSLNDKLNDYTQLLPPTPEYSNENEEFDDDDFSIADINDDDIPSIQTIDDKMELKFRQPIEGVNIDYARNAVVLKFHKNNAKSMMKMNTLESEKKKSVQDNFIRFGKRSYEEFPLVNSLDEGFGLKNAGMRLERSHQTARDARGDNFMRFGRSANTKNDFMRFGRGGNDFMRFGRSPTQDFMRFGRAAASDNFMRFGRQANQDFMRFGRAAGQDFMRFGRSPSQDFMRFGRSPSQDFMRFGRSPSQDFMRFGRSPSQDFMRFGRTPSQDFMRFGRAPSQDFMRFGRAGQDNFMRFGRNPQQDFMRFGRTPQQDFMRFGRNTPKIPQNFMRYSRPDNFMRFGRTPPQPSDNFIRFGKSIEKSNDKNSSQPLLGKNELKQAVKLIHEADKNADNENPVDKAIKVLFDKHQQQDQDDKVHSNELNLDSSNQHNDNNDNTELDSDLDYFLK
  • Signal peptide:  FSFNKVLFLALQLCYTQTLS
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-A0A0L0BTP1-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001392_AF2.pdbhor001392_ESM.pdb

Physical Information

Mass: 161494 Formula: C65H95N17O19
Absent amino acids: ACEGHKLMVWY Common amino acids: P
pI: 6.34 Basic residues: 1
Polar residues: 3 Hydrophobic residues: 3
Hydrophobicity: -93.33 Boman Index: -3091
Half-Life: 7.2 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 32.5
Instability Index: 6084.17 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  23280433
  • Title:  Neuropeptidomics of the Australian Sheep Blowfly Lucilia Cuprina (Wiedemann) and Related Diptera